The dynamic consequences of amygdala damage on threat processing in Urbach-Wiethe Disease. A commentary on Pishnamazi et al. (2016)


We place the timely study of Pishnamazi et al. (2016) in the context of outstanding issues in the literature on amygdala damage in UWD. While the study by Pishnamazi et al. provides new evidence it also may add to the existing confusion in the literature. We discuss how damage to the amygdala due to UWD has heterogeneous consequences for threat processing and we offer several considerations for future research. We conclude that further progress in understanding the role of the amygdala requires us to move beyond attributing a single role to the amygdala, to focus on its sub-nuclei and study the dynamic interaction between subnuclei damage and associated neural network.